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Our study investigates the effect of hybrid courses and reading articles on the   scientific literacy of biomedical engineering students. About 100 advanced undergraduate and graduate students participated in one or two of the courses titled From Cell to Tissue and Tissue Engineering. The courses required active participation in the face-to-face lectures, as well as weekly participation in asynchronous forum discussions on state-of-the-art scientific articles. Research tools included pre- and post-questionnaires and analysis of students’ forum discourse.